Hcy、凝血指标与不良妊娠的关系及对再次妊娠结局的预测价值OA

Objective:To explore the correlation between homocysteine(Hcy),coagula-tion indicators and adverse pregnancy outcomes and the predictive value of pregnancy out-comes.Methods:A total of 182 patients with second pregnancy admitted to our hospital from June 2021 to June 2025 were selected as the research object,and they were divided into a good pregnancy group(120 cases)and an adverse pregnancy group(62 cases)according to the sec-ond pregnancy outcome.The adverse outcome of second pregnancy was analyzed by univariate analysis and binary logistic regression analysis,and the area under the ROC curve was used to evaluate the predictive efficacy of Hcy and coagulation indicators on the model.Results:The prothrombin time(PT)and thromboplastin time(APTT)in the poor pregnancy group were low-er than those in the good pregnancy group,while the positive rates of Hcy,D-Dimer(D-D),fi-brinogen(FIB)and lupus anticoagulant(LA)were higher than those in the good pregnancy group(P<0.05).Multivariate regression showed that Hcy,D-D,FIB and LA were independent predictors of adverse outcomes of second pregnancy.The area under the curve(AUC)was 0.842(95%CI:0.766～0.908),0.862(95%CI:0.803～0.921),0.735(95%CI:0.660～0.809),0.644(95%CI:0.554～0.734),0.971(95%CI:0.942～1.000),respectively.When the cut-off value was taken,the sensitivity was 0.758,0.710,0.694,0.933,0.942,and the specificity was 0.783,0.925,0.683,0.355,0.935,respectively.Conclusion:Hcy,D-D,FIB,LA are all independent risk factors for adverse outcomes of second pregnancy,which have a certain reference value for predicting adverse outcomes of second pregnancy.