神经母细胞瘤患儿临床检测免疫功能指标的意义OA

Objective To explore the significance of immune function indicators in the clinical examination of children with neuroblastoma(NB).Methods The clinical data of 393 pediatric patients with NB(199 males,194 females)treated at Beijing Chil-dren's Hospital Affiliated to Capital Medical University from 2018 to 2023 were retrospectively analyzed,while 67 normal healthy chil-dren(38 males,29 females)who underwent physical examinations during the same period were selected as the control group.At initial evaluation,serum immunoglobulins(IgG,IgA,IgM)and total IgE were compared between the two groups.Through cellular immunity in blood and flow cytometry,the levels of peripheral blood T lymphocytes(CD3+,CD4+,CD8+,CD4+/CD8+),B cells(CD19+),and natural killer(NK)cells(CD16+CD56+)were detected.Results NB predominantly affected children aged 0-3 years(n=208 in this cohort).Compared with healthy controls,children with NB had significantly lower levels of CD3+,CD4+,and CD4+/CD8+,and significantly higher levels of CD8+and NK cells,with statistically significant differences between the two groups(P<0.05).No signifi-cant difference was observed in the level of B cells(Z=-1.909,P=0.056).The levels of IgG,IgA,and IgE were significantly high-er in the NB group than i those in the control group,and the differences were statistically significant(P<0.05),whereas the level of IgM showed no significant difference.Conclusions Pediatric NB is associated with dysregulation of both cellular and humoral immuni-ty.Monitoring the levels of lymphocyte subsets and Ig series in children may facilitate the evaluation of the cellular and humoral im-mune functions of the affected children.