苹果木栽培的牛樟芝抑制结直肠癌细胞增殖活性的研究OA

In order to study the inhibitory effect of Antrodia cinnamomea cultivated on apple wood on colorectal cancer cells in vivo and in vitro.The MTT method was used to detect the inhibitory rate of Antrodia cinnamomea extract on the proliferation of HT29 and HCT116 cell lines with different concentrations.The effect of the extract on the tumor growth of Antrodia cinnamomea was detected in a colorectal cancer xenograft mouse model by gavage technique.The results showed that in vitro the extracts of Antrodia cinnamomea cultivated on ap-ple wood have inhibitory effects on the proliferation of human colorectal cancer HT29 and HCT116 cells,and the half inhibition rates of the cells are(26.15±6.41)mg/L and(20.09±3.07)mg/L;In vivo the extract of Antrodia cinnamomea cultivated on apple wood can inhibit the growth of tumors in human colorectal cancer HT29 tumor-bearing mice(P＜0.05),Antrodia cinnamomea cultivated on apple wood effectively in-hibits the proliferation of human colorectal cancer cells in vitro,and the high-dose extract exhibits significantly antitumor activity in vivo,providing an experimental basis for its potential clinical application in the treatment of colorectal cancer.