色氨酸代谢重编程驱动肿瘤免疫逃逸的机制及中药增敏免疫治疗的研究进展OA
Research advances in mechanisms of tryptophan metabolic reprogramming-driven tumor immune escape and immune sensitization therapy of traditional chinese medicine
色氨酸代谢作为连接免疫调控与肿瘤进展的重要枢纽,近年来成为癌症研究的前沿领域.首先,从代谢酶的功能异质性切入,阐述其在肿瘤免疫微环境(tumor microenvironment,TME)中通过色氨酸(tryptophan,TRP)耗竭与犬尿氨酸(kynurenine,KYN)积累调控免疫细胞的分子路径;其次,结合乳腺癌、结直肠癌、胶质瘤、上皮性卵巢癌的代谢特征,分析肿瘤类型特异性;最后,中药单体和复方通过TRP代谢通路调控TME.本文旨在为突破肿瘤代谢屏障、优化免疫治疗响应提供理论依据.
As a crucial hub that links immune dysregulation and tumor progression,tryptophan metabo-lism has emerged as a transdisciplinary frontier in cancer research.This review initially delineates the functional heterogeneity of tryptophan-catabolizing enzymes and their molecular pathways that govern immune cell dynamics in the tumor microenvironment(TME)through dual mechanisms:tryptophan depletion and kynurenine(KYN)ac-cumulation.Subsequently,by concentrating on the metabolic characteristics of breast cancer,colorectal cancer,glioma,and epithelial ovarian cancer,we systematically analyze the histotype-specific reprogramming of trypto-phan metabolism.Finally,we assess the regulatory effects of traditional Chinese medicine(TCM)active ingredi-ents(monomers and compound formulas)on reshaping the TME by targeting tryptophan metabolic pathways.This review aims to offer mechanistic and translational insights for surmounting tumor metabolic adaptation barriers and enhancing immunotherapy efficacy.
张文洁;孙硕;任志悦;宫雨萌;孙有智;赵益
江西中医药大学中医基础理论分化发展研究中心(江西南昌 330004)江西中医药大学方-证研究中心(江西南昌 330004)江西中医药大学方-证研究中心(江西南昌 330004)江西中医药大学中医基础理论分化发展研究中心(江西南昌 330004)江西中医药大学方-证研究中心(江西南昌 330004)江西中医药大学中医基础理论分化发展研究中心(江西南昌 330004)
医药卫生
色氨酸代谢重编程犬尿氨酸通路吲哚胺-2,3-双加氧酶1肿瘤免疫逃逸程序性死亡配体1中药增敏免疫治疗
tryptophan metabolic reprogrammingkynurenine pathwayindoleamine 2,3-dioxygenase 1tumor immune escapeprogrammed death-ligand 1immune sensitization therapy of traditional Chinese medicine
《实用医学杂志》 2026 (9)
1525-1535,11
国家自然科学基金项目(编号:82360961)江西省自然科学基金项目(编号:20242BAB25562)
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