三酰甘油-葡萄糖指数与2型心肌梗死患者发生主要不良心血管事件的关系研究OA

Objective To investigate the association between triglyceride-glucose(TyG)index and major adverse cardiovascular events(MACE)in patients with type 2 myocardial infarction(T2MI).Methods A total of 509 patients with T2MI admitted to Department of Cardiology in Cangzhou People's Hospital from 2019 to 2021 were retrospectively selected as the research subjects.The clinical data of the patients were collected,and patients were divided into low group(TyG index≤8.61,n=171),intermediate group(8.61<TyG index≤9.10,n=169),and high group(TyG index>9.10,n=169)according to the TyG index tertiles.Follow-up for 3 years was performed to record the occurrence of MACE of patients.Multivariate Cox proportional hazards regression analysis was used to explore the influencing factors of MACE in patients with T2MI;restricted cubic spline analysis was used to explore the relationship between TyG index and the risk of MACE in patients with T2MI;and ROC curve analysis was used to explore the predictive value of the TyG index for MACE in patients with T2MI.Results Among 509 patients with T2MI,107 cases(21.02%)developed MACE.There were statistically significant differences in age,body mass index,heart rate,the proportion of patients with history of diabetes,the proportion of patients with history of hyperlipidemia,white blood cell count,platelet count,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and incidence of MACE among the three groups(P<0.05).The proportion of male patients with MACE was higher than that without MACE,the age was older than that without MACE,the heart rate was faster than that without MACE,the proportions of patients with history of diabetes and history of old myocardial infarction,left ventricular ejection fraction(LVEF),white blood cell count,C-reactive protein(CRP),brain natriuretic peptide(BNP),troponin I(TnI)peak,the proportion of patients taking beta blockers during hospitalization,TyG index were higher than those without MACE,hemoglobin,estimated glomerular filtration rate(eGFR)were lower than those without MACE(P<0.05).Multivariate Cox proportional hazards regression analysis showed that TyG index was an independent influencing factor for MACE in patients with T2MI[HR=1.512,95%CI(1.102-2.073),P<0.05].The restricted cubic spline analysis showed that the TyG index was linearly positively correlated with the risk of MACE in patients with T2MI(Poverall<0.001,Pnon-linear=0.133).ROC curve analysis results showed that the AUC of TyG index for predicting MACE in patients with T2MI was 0.677[95%CI(0.630-0.724)].Conclusion The TyG index is an independent influencing factor for MACE in patients with T2MI,and there is a linear positive correlation between the TyG index and the risk of MACE in patients with T2MI.