阻塞性睡眠呼吸暂停与肠道菌群相互作用的研究进展OA

Obstructive sleep apnea(OSA)is a common chronic sleep-related breathing disorder,characterized primarily by in-termittent hypoxia and sleep fragmentation resulting from the recurrent collapse of the upper airway during sleep.Studies indicat-ed that disturbances of the gut microbiota represent a crucial intermediary mechanism in the multi-system pathological damage and development of comorbidities induced by OSA.Changes in the gut microbiota under OSA conditions,including abnormalities in α/β diversity,enrichment of anaerobic bacteria,reduction in short-chain fatty acid-producing bacteria,as well as alterations in metabolic profiles such as bile acids,amino acids,and fatty acids,were systematically elucidated.Furthermore,the key driv-ing role of gut microbiota and their metabolites in OSA-related comorbidities,such as hypertension and atherosclerosis,was ex-tensively investigated.Concurrently,research progress on intervention strategies targeting the gut microbiome was comprehen-sively integrated.These findings provide new perspectives and a foundation for mechanistic research and clinical management of OSA.