首页|期刊导航|世界科学技术-中医药现代化|从"小结胸"证探讨化痰类中药在贲门癌前病变中的应用

从"小结胸"证探讨化痰类中药在贲门癌前病变中的应用OA

Discussion on the Application of Herbs that Dissolve Phlegm in the Treatment of Gastric Cardia Precancerous Lesions from the Perspective of"Minor Chest Binding"Syndrome

中文摘要英文摘要

贲门癌前病变是常见的上消化道慢性疾病,具有较高的"炎—癌"转化风险而严重危害人民健康,早期诊治对于阻断其进展及癌变具有重要的意义."小结胸"证是《伤寒论》太阳病变证之一,以痰热互结于心下为基本病机.本文通过分析贲门癌前病变的发生发展特征,发现其与"小结胸"证的形成有着密切的联系,认为该病的核心病机为饮食不节、五志化火等因素所酿生的痰、热病理产物结聚衍化、变生瘀血,最终胶结黏滞、盘踞成毒;据此提出以痰为核心的论治法则,运用化痰类中药"降痰""解痰""稳痰",以除病之"源"、破病之"胶"、防病之"变",以期为贲门癌前病变的临床诊治提供新的视角和思路.

Gastric cardia precancerous lesions are common chronic diseases of the upper gastrointestinal tract.They have a high risk of"inflammation-cancer"transformation and seriously endanger people's health.Early diagnosis and treatment are of great significance for blocking their progression and canceration course."Minor chest binding"syndrome is one of the complications of Taiyang syndromes in the Treatise on Febrile Diseases,and its basic pathogenesis is phlegm and heat binding under the heart.This paper analyzes the occurrence and development characteristics of gastric cardia precancerous lesions and finds that it is closely related to the formation of"minor chest binding"syndrome.It is believed that the core pathogenesis of the disease is that the phlegm and heat pathological products caused by factors such as improper diet and five emotions transforming into fire gather and evolve,transform into blood stasis,and finally become sticky and entrenched into poison.Based on this,a treatment principle focus on phlegm as the core is proposed,and the phlegm-resolving herbs is used to"descend phlegm","untie phlegm"and"stabilize phlegm"to eliminate the"source",break the"glutinosity"and prevent the"change"of the disease,in order to provide a new perspective and idea for the clinical diagnosis and treatment of gastric cardia precancerous lesions.

刘思达;刘乃华;崔永超;高永;史亚飞;潘华峰

广州中医药大学 广州 510405广州中医药大学 广州 510405广州中医药大学 广州 510405广州中医药大学 广州 510405广州中医药大学 广州 510405广州中医药大学 广州 510405

医药卫生

小结胸证贲门癌前病变化痰类中药中医理论伤寒论

"Minor Chest Binding"SyndromeGastric cardia precancerous lesionsHerbs that dissolve phlegmTraditional Chinese medicine theoryThe Treatise on Febrile Diseases

《世界科学技术-中医药现代化》 2026 (4)

1103-1110,8

国家自然科学基金委员会面上项目(82174319):基于"虚瘀毒"病机探讨健脾化瘀解毒法调控ANGPTL2/α5β1介导胃"炎-癌"转化增殖迁移机制研究,负责人:潘华峰广东省重点领域研发计划(2020B1111100011):胃"炎-癌"微环境证候演变规律及扶正为主病证结合研究,负责人:潘华峰广州中医药大学校院联合科技创新基金(GZYSE2024Y03):基于CD44/Cu2+介导巨噬细胞代谢重编程探讨舌象映射的GPL"瘀毒互结"病机实质及健脾化瘀解毒方干预机制,负责人:刘思达.

10.11842/wst.20250509002

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