中药单体调控JAK/STAT信号通路干预椎间盘退变的研究进展OA
Research progress on regulation of JAK/STAT signaling pathway by bioactive monomers in Chinese materia medica for intervention in intervertebral disc degeneration
综述杨梅素、花青素、丹酚酸B、白藜芦醇、红景天苷、隐丹参酮、山莨菪碱等多种中药单体,其可通过调控Janus酪氨酸蛋白激酶(JAK)/信号转导及转录活化因子(STAT)信号通路,调节磷酸化JAK(p-JAK)、p-STAT蛋白水平,下调炎症因子与基质降解酶、促进细胞外基质合成、增强自噬与抗氧化能力等途径,显著改善椎间盘退变的病理变化.
This article reviews various bioactive monomers derived from Chinese materia medica,such as myricetin,anthocyanins,salvianolic acid B,resveratrol,salidroside,cryptotanshinone,and anisodamine.These monomers can significantly ameliorate the pathological changes of intervertebral disc degeneration(IVDD)through regulating the Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway.Specifically,they modulate the protein levels of phosphorylated JAK(p-JAK)and phosphorylated STAT(p-STAT),downregulate inflammatory cytokines and matrix-degrading enzymes,promote the synthesis of extracellular matrix,and enhance autophagy and antioxidant capacity,significantly improve the pathological changes of intervertebral disc degeneration.
杨龙;郭铁峰;刘晏东;李军杰;罗林钊;郭洁;左鹏;张彦军
甘肃中医药大学(甘肃 兰州 730000)甘肃省中医院(甘肃 兰州 730050)甘肃省中医院(甘肃 兰州 730050)甘肃省中医院(甘肃 兰州 730050)甘肃省中医院(甘肃 兰州 730050)甘肃中医药大学(甘肃 兰州 730000)甘肃中医药大学(甘肃 兰州 730000)甘肃省中医院(甘肃 兰州 730050)
椎间盘退变腰痛中药单体Janus酪氨酸蛋白激酶信号转导及转录活化因子作用机制
intervertebral disc degenerationlumbodyniaChinese materia medica monomersJanus kinasesignal transducer and activator of transcriptionmechanism of action
《上海中医药杂志》 2026 (5)
77-85,9
国家自然科学基金项目(82360947)国家中医药管理局重大疑难疾病中西医临床协作项目(ZDYN-2024-A-145)甘肃省卫健委卫生健康行业科技创新重大科研项目(GSWSZD2024-04)2024年甘肃省委组织部省级人才项目(甘组通字:2024-4)
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