艾灸联合西药治疗寒湿痹阻型类风湿关节炎的疗效观察OA
Observation on the therapeutic efficacy of moxibustion combined with Western medicine for rheumatoid arthritis of cold dampness obstruction pattern
目的 观察不同艾灸方法联合西药治疗寒湿痹阻型类风湿关节炎(rheumatoid arthritis,RA)的临床疗效.方法 将 96 例寒湿痹阻型 RA 患者随机分为西药组、灸盒组和温通灸组,每组 32 例.西药组予口服甲氨蝶呤片治疗,灸盒组在西药组治疗基础上采用艾灸盒进行艾灸治疗,温通灸组在西药组治疗基础上采用温通灸器具进行艾灸治疗.观察 3 组治疗前后压痛关节计数、肿胀关节计数、28 个关节疾病活动度评分(disease activity score in 28 joints,DAS28)、疼痛视觉模拟量表(visual analog scale,VAS)评分、中医证候积分、健康评价问卷(health assessment questionnaire,HAQ)评分以及各项实验室指标[红细胞沉降率(erythrocyte sedimentation rate,ESR)、血清C-反应蛋白(C-reactive protein,CRP)和类风湿因子(rheumatoid factor,RF)水平、血小板计数(platelet count,PLT)以及血红蛋白(hemoglobin,HB)水平]的变化,比较3 组临床疗效,比较两组艾灸治疗组的操作前准备时长.结果 温通灸组总有效率为 90.6%,高于西药组的 62.5%和灸盒组的81.3%,组间差异具有统计学意义(P<0.05).温通灸组操作前准备时长短于灸盒组(P<0.05).治疗后,3 组肿胀关节数、VAS评分、血清RF和 CRP 水平、ESR、DAS28和 HAQ 评分均较同组治疗前降低(P<0.05);且温通灸组上述指标均低于灸盒组和西药组(P<0.05),灸盒组上述指标均低于西药组(P<0.05).治疗后,3 组中医证候积分均较同组治疗前降低(P<0.05),且温通灸组中医证候积分低于其余两组(P<0.05).治疗后,3 组血小板计数均较同组治疗前降低(P<0.05);且温通灸组血小板计数低于西药组(P<0.05),灸盒组血小板计数低于西药组(P<0.05).治疗后,3 组血红蛋白含量均较同组治疗前升高(P<0.05);且温通灸组血红蛋白含量高于西药组(P<0.05),灸盒组血红蛋白含量高于西药组(P<0.05).结论 在西药治疗基础上,温通灸器具艾灸治疗寒湿痹阻型RA 的临床疗效优于灸盒艾灸治疗,可改善临床症状,降低疾病活动度,减轻炎症反应,提高患者生活质量.
Objective To observe the clinical efficacy of different moxibustion methods combined with Western medicine in treating rheumatoid arthritis(RA)of cold dampness obstruction pattern.Method Ninety-six patients with RA of cold dampness obstruction pattern were randomly allocated to a Western medicine group,a moxibustion box group,and a Wen Tong(warm unblocking)moxibustion group,with 32 cases in each group.The Western medicine group received oral administration of Methotrexate tablets.In addition to the intervention in the Western medicine group,the moxibustion box group received moxibustion treatment using moxibustion boxes,and the Wen Tong moxibustion group received moxibustion using a specific device.The three groups were observed for post-treatment changes in the tender joint count,swelling joint count,disease activity score in 28 joints(DAS28),visual analog scale(VAS)score,traditional Chinese medicine(TCM)symptom score,health assessment questionnaire(HAQ)score,and laboratory indicators[erythrocyte sedimentation rate(ESR),serum C-reactive protein(CRP),rheumatoid factor(RF)level,platelet count(PLT),and hemoglobin(HB)content].The clinical efficacy was compared among the three groups,and the preparation duration before operation was compared between the two moxibustion groups.Result The Wen Tong moxibustion group achieved a total effective rate of 90.6%,higher than that of 62.5%in the Western medicine group and 81.3%in the moxibustion box group,showing statistical significance(P<0.05).The pre-operation preparation duration was shorter in the Wen Tong moxibustion group than in the moxibustion box group(P<0.05).After treatment,the swelling joint count,VAS score,serum RF and CRP levels,ESR,DAS28,and HAQ score decreased in all the three groups(P<0.05);these values were smaller or lower in the Wen Tong moxibustion group than in the other two groups(P<0.05),and were smaller or lower in the moxibustion box group than in the Western medicine group(P<0.05).After intervention,the three groups all demonstrated a decrease in the TCM symptom score(P<0.05),and the score in the Wen Tong moxibustion group was lower than that in the other two groups(P<0.05).The PLT dropped after treatment in the three groups(P<0.05);the count was smaller in the Wen Tong moxibustion group and the moxibustion box group than in the Western medicine group(P<0.05).The HB content increased after treatment in all three groups(P<0.05);the content was higher in the two moxibustion groups than in the Western medicine group(P<0.05).Conclusion Based on Western medicine,moxibustion with a Wen Tong moxibustion device produces more significant clinical efficacy than moxibustion box moxibustion in treating RA of cold dampness obstruction pattern;Wen Tong moxibustion can improve clinical symptoms,reduce disease activity,ease inflammatory responses,and enhance the patient's quality of life.
顾博文;刘丹;徐美丽;徐璇;刘梨;龚志贤;张亮;艾坤;常小荣;徐豫湘
湖南中医药大学第一附属医院,长沙 410007||湖南中医药大学,长沙 410208湖南中医药大学第一附属医院,长沙 410007湖南中医药大学第一附属医院,长沙 410007湖南中医药大学第一附属医院,长沙 410007||湖南中医药大学,长沙 410208湖南中医药大学第一附属医院,长沙 410007湖南中医药大学第一附属医院,长沙 410007湖南中医药大学,长沙 410208湖南中医药大学,长沙 410208湖南中医药大学,长沙 410208湖南中医药大学第一附属医院,长沙 410007
医药卫生
灸法针灸器械针药并用关节炎,类风湿疼痛水肿寒湿痹阻
MoxibustionAcupuncture-moxibustion apparatusAcupuncture medication combinedArthritis,RheumatoidPainSwellingCold dampness obstruction
《上海针灸杂志》 2026 (4)
352-358,7
国家自然科学基金项目(82274627,82074565)湖南省中医药管理局重点项目(A2023010)湖南省"十四五"中医药骨干人才项目(2023年)
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