活血化瘀中药调控VEGF信号通路抑制血管翳生成治疗类风湿关节炎的研究进展OA
Research progress on traditional Chinese medicines for promoting blood circulation and removing blood stasis regulating VEGF signaling pathway to inhibit pannus formation in rheumatoid arthritis
类风湿关节炎(RA)是一种常见的慢性自身免疫性疾病,主要病理特征为滑膜炎症与增生、抗体生成、侵袭性新生血管翳形成、软骨和骨的破坏性改变.血管翳是RA病理过程中的关键环节,可被血管内皮生长因子(VEGF)调控.活血化瘀中药(丹参、紫草及穿山龙等)及活血化瘀中药复方(清热活血方、瘀血痹片及二四汤等)均可通过改善血瘀状态,调控VEGF通路,抑制血管翳生成,延缓RA的发展.深入了解活血化瘀中药及复方通过调控VEGF通路抑制血管翳形成的机制及临床价值,可为RA的中西医结合治疗提供理论支持.
Rheumatoid arthritis(RA)is a common chronic autoimmune disease,with main pathological features in-cluding synovial inflammation and hyperplasia,antibody production,invasive neovascular pannus formation,and destruc-tive changes in cartilage and bone.Pannus,a key link in RA pathology,is regulated by vascular endothelial growth factor(VEGF).Traditional Chinese medicines for promoting blood circulation and removing blood stasis[Danshen(Salvia milti-orrhiza),Zicao(Lithospermum erythrorhizon),and Chuanshanlong(Dioscorea nipponica),etc.],and their compound formulas including Qingre Huoxue Formula,Yuxuebi Tablet,Ersi Decoction,etc.can improve the"blood stasis"state,regulate the VEGF pathway,inhibit pannus formation,and delay RA progression.A deeper understanding of their mecha-nisms and clinical value in inhibiting pannus via regulating the VEGF pathway provides theoretical support for the integra-tive treatment of RA with traditional Chinese and Western medicine.
刘婷;赵啸虎;刘源;姜萍;考希良
山东中医药大学第一临床医学院,山东济南 250014山东中医药大学第一临床医学院,山东济南 250014山东中医药大学第一临床医学院,山东济南 250014山东中医药大学第一临床医学院,山东济南 250014山东中医药大学第一临床医学院,山东济南 250014
医药卫生
活血化瘀类中药血管翳血管内皮生长因子类风湿关节炎
traditional Chinese medicines for promoting blood circulation and removing blood stasispannusvascu-lar endothelial growth factorrheumatoid arthritis
《山东医药》 2026 (3)
154-158,5
国家自然科学基金面上项目(82274481)国家中医药管理局科技司共建科技项目(GZY-KJS-SD-2023-041)山东省卫生健康科创团队建设项目(2024sdskctd-03)山东省自然科学基金(ZR2022LZY004)齐鲁医派中医学术流派传承项目[鲁卫函(2022)93号].
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