系统性免疫炎症指数与预后营养指数对腹膜透析相关腹膜炎的预测价值OA

Objective To evaluate the predictive value of the systemic immune-inflammation index(SII)and the prognostic nutritional index(PNI)for peritoneal dialysis-associated peritonitis(PDAP).Methods Sixty-three patients undergoing peritoneal dialysis(PD)and diagnosed with PDAP were enrolled in the study,while 48 PD patients without PDAP during the same period were selected to serve as controls.General data and laboratory parameters,including hemo-globin,neutrophil count,lymphocyte count,platelet count,serum potassium,serum calcium,serum phosphorus,serum albumin,high-density lipoprotein cholesterol,and serum creatinine,were collected.The SII and PNI were subsequently calculated.Logistic regression analysis was employed to identify factors influencing PDAP.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of SII and PNI for the occurrence of PDAP in PD patients.Results PDAP patients showed lower levels of serum potassium,serum calcium,hemoglobin,serum albumin,lympho-cyte count,and PNI,but higher levels of neutrophil count,platelet count,and SII than the non-PDAP patients(all P＜0.05).Multivariate Logistic regression analysis identified SII and PNI as independent influencing factors for PDAP devel-opment in PD patients(all P＜0.05).The areas under the curve for predicting PDAP were 0.810 for SII,0.874 for PNI,and 0.905 for their combination.The corresponding sensitivities were 0.603,0.778,and 0.778;and specificities were 0.917,0.833,and 0.896,respectively.Conclusion SII and PNI are independent influencing factors for PDAP in PD pa-tients,and their combination demonstrates favorable predictive value.