胃腺癌组织自噬相关基因13蛋白表达变化及其对患者预后的影响OA

Objective To investigate the expression changes of autophagy-related gene 13(ATG13)protein in gastric adenocarcinoma tissues and to analyze its effect on prognosis of patients.Methods Immunohistochemistry(IHC)was performed to assess ATG13 protein expression in 99 cases of primary gastric adenocarcinoma biopsy tissues and in 71 cases of adjacent tissues.ATG13 protein expression was compared among patients with different clinicopathological characteristics.Kaplan-Meier survival analysis was used to compare overall survival(OS)between patients with high and low ATG13 ex-pression.In addition,a Cox proportional hazards regression model was applied to identify risk factors for poor prognosis in patients with gastric adenocarcinoma.Results The high-expression rate of ATG13 protein was significantly higher in the gastric adenocarcinoma tissues than in the adjacent tissues(P＜0.05).Compared with patients with low ATG13 expression,those with high ATG13 expression had a larger maximum tumor diameter(P＜0.05).No significant differences were found between the two groups in age,sex,depth of tumor invasion,lymph node metastasis,distant metastasis,clinical stage,or pathological grade(all P＞0.05).Kaplan-Meier survival analysis indicated that OS was shorter in patients with high ATG13 expression than in those with low ATG13 expression(P＜0.05).Univariate Cox regression analysis showed that clinical stage,lymph node metastasis,distant metastasis,and ATG13 expression were associated with poor prognosis(all P＜0.05).Multivariate Cox regression analysis further demonstrated that distant metastasis and high ATG13 expression were in-dependent risk factors for poor prognosis in patients with gastric adenocarcinoma(all P＜0.05).Conclusion ATG13 pro-tein is highly expressed in gastric adenocarcinoma tissues,and high ATG13 expression is closely associated with poor prog-nosis in patients with gastric adenocarcinoma.