子宫内膜癌的分子分型:对临床实践的影响和未来探索的问题OA

Molecular classification of endometrial cancer has become a new cornerstone of precision diagnosis and treat-ment.In 2013,The Cancer Genome Atlas project proposed four molecular subtypes:POLE ultramutated,microsatellite in-stability,copy-number low,and copy-number high.Simplified classification strategies such as ProMisE and TransPORTEC have made clinical application possible.Molecular classification has significant implications for preoperative surgical deci-sion-making,postoperative adjuvant therapy planning,fertility-sparing treatment,and Lynch syndrome screening.Howev-er,clinical application still faces challenges in testing accessibility,clinical prognostic heterogeneity,and interpretation of mixed molecular features.Future research should explore more convenient and accurate classification methods,establish secondary stratification systems for highly heterogeneous subtypes such as no specific molecular profile(NSMP),and vali-date classification-based treatment strategies through prospective clinical trials to ultimately construct a dynamic,precise,accessible new paradigm for comprehensive endometrial cancer management.