没食子酸通过β受体影响牛蛙心肌收缩活动OA

To explore the mechanism underlying the effects of gallic acid on cardiac contractile activity,this experiment employed the isolated frog heart perfusion technique.Different concentrations of gallic acid(0mg·L-1,2.5 mg·L-1,5 mg·L-1,and 10 mg·L-1)were perfused,and the BL-422i Data Acquisition System(Taimeng)was used to record the impacts of these concentrations on myocardial contractile force and heart rate in bullfrogs.The results showed that compared with the control group,different concentrations of gallic acid had no significant difference in heart rate.There was no significant change in myocardial contractile force in the 2.5 mg·L-1 group relative to the control group,while the 5 mg·L-1 and 10 mg·L-1 gallic acid groups exhibited an extremely significant inhibitory effect on myocardial contractile force compared with the control group.After perfusing the bullfrog heart with 5 mg·L-1 gallic acid(GA)and observing the inhibitory effect,subsequent addition of epinephrine restored the myocardial contractile capacity.However,no significant change in the bullfrog heart was observed when 5 mg·L-1 GA was administered after propranolol hydrochloride treatment.