ANGPTL4在糖尿病视网膜病变中的作用机制及治疗靶点研究进展OA

·Diabetic retinopathy(DR)remains the leading cause of vision loss in patients with diabetes.Current anti-vascular endothelial growth factor(VEGF)therapies are limited by inadequate response in some patients and the necessity for repeated intravitreal injections,underscoring the urgent need for novel therapeutic targets.Angiopoietin-like protein 4(ANGPTL4),a multifunctional secreted protein,has emerged as a critical regulator in the pathogenesis and progression of DR,positioning it as a promising interventional target.This review systematically elaborates the biological characteristics of ANGPTL4,with a focus on its expression dynamics,molecular mechanisms,and regulatory networks rolesin the development of DR.Furthermore,the prospects of ANGPTL4-targeted therapeutic strategies are discussed,aiming to offer new insights and directions for understanding DR pathogenesis,advancing multi-target drug development,and improving clinical management.