抗菌缝合线的研究进展OA

To mitigate the risk of infection at surgical site associated with conventional surgical sutures and to alleviate patient discomfort,the latest research progress of anti-bacterial sutures were summarized systematically from perspective of surgical sutures functional modification.Antimicrobial substances,action mechanisms and their respective advantages&disadvantages of four major antibacterial modification technologies adopted in soaking,grafting,body spinning and intelligent modification were contrasted and analyzed as keys.The research pointed out that the key challenges faced by current antimicrobial sutures including the mismatch between the kinetics of drug release and the stages of wound healing,reduction in mechanical strength resulting from functionalization,as well as difficulties in clinical translation and application.It is necessary to explore drug-free antimicrobial strategies,emphasize the importance of developing smart-responsive materials and encourage the promotion of multifunctional smart integration to advance the evolution of antimicrobial sutures towards a more precise and intelligent framework.