手性三唑类杀菌剂立体选择性生物活性与毒性效应研究进展OA

Triazole fungicides are widely used to prevent various fungal diseases of vegetables,fruits,and other crops during the production process due to their advantages of high efficiency,low toxicity,broad spectrum and short half-life.With the excessive use of pesticides,pesticides residues can remain in food and the environment,which are potentially harmful to human health and ecological safety.Chiral triazole fungicides have one or more chiral centers with stereoselective bioactivity and toxicity.Therefore,it is of great significance to fully understand their differences for the development of environmentally friendly optically pure monomer pesticides.This paper reviews the stereoselective bioactivities,acute toxicities,developmental toxicities,oxidative stress toxicities of chiral triazole fungicides,and endocrine-disrupting effects on non-target organisms.Moreover,the relationship between enantiomer bioactivity and acute toxicity was summarized,which provided a reference for the development of low toxicity and high efficiency optical pure monomer pesticides.