胃癌中的铁死亡机制及其潜在治疗靶点研究进展OA
Ferroptosis in gastric cancer:mechanisms and potential therapeutic targets
铁死亡近年来逐渐受到研究者的关注,其在肿瘤细胞的增殖和迁移中具有重要作用,同时也影响着肿瘤的发生和发展.尽管目前对铁死亡的研究取得了一定进展,但在胃癌领域,其具体机制及与其他细胞死亡方式的相互作用仍需深入探讨.此外,研究者们也在努力寻找针对铁死亡的治疗靶点,以期为胃癌治疗提供新的思路和策略.本综述旨在系统分析铁死亡在胃癌发病机制中的作用,评估其作为潜在治疗靶点的可行性,并探讨未来的研究方向和临床应用前景.
In recent years,ferroptosis has garnered increasing attention among researchers.Ferroptosis not only plays a pivotal role in proliferation and migration of tumor cells,but also influences tumor initiation and progression.Although significant progress has been made in ferroptosis research,the specific mechanisms underlying its function in gastric cancer,particularly its interplay with other cell death modalities,require further elucidation.Concurrently,researchers are actively exploring therapeutic targets related to ferroptosis to develop novel strategies for gastric cancer treatment.This review systematically analyzes the role of ferroptosis in the pathogenesis of gastric cancer,evaluates its feasibility as a potential therapeutic target,and discusses future research directions and clinical application prospects.
张哲恺;张观议;赵琰;陈晓杰;王志贤;陈玉洁
联勤保障部队第九八○医院卫勤部,石家庄 050082联勤保障部队第九八○医院卫勤部,石家庄 050082联勤保障部队第九八○医院卫勤部,石家庄 050082联勤保障部队第九八○医院卫勤部,石家庄 050082联勤保障部队第九八○医院卫勤部,石家庄 050082联勤保障部队第九八○医院门诊部,石家庄 050082
胃肿瘤铁死亡细胞死亡治疗靶点生物标志物综述
gastric cancerferroptosiscell deaththerapeutic targetsbiomarkersreview
《临床误诊误治》 2026 (8)
104-110,7
河北省医学科学研究课题计划(20242222)
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