基于孟德尔随机化与中医视角探讨黄褐斑与时型的因果关联OA

Objective To investigate the causal association between melasma and chronotype,leveraging the Mendelian randomization(MR)method and incorporating perspectives from Traditional Chinese Medicine(TCM).Methods First,the chloasma data were obtained from the FinnGen Finnish biobank and the morningness/eveningness phenotype data from the IEU open GWAS,and instrumental variables(Ⅳ)were screened accordingly.Interfering single nucleotide polymorphisms(SNPs)were then removed using the Mendelian Randomization(MR)Pleiotropy Residual Sum and Outlier(MR-PRESSO)test to ensure the quality of IVs.Subsequently,inverse variance weighting(IVW),MR-Egger regression,and the weighted median method were employed for MR analysis.The MR-Egger intercept test was used to evaluateⅣ pleiotropy,and Cochran's Q test was applied to assess heterogeneity.Meanwhile,the results were visualized through forest plots and scatter plots.Results The IVW method showed a significantly positive correlation between chronotype and melasma(OR=0.007,95％CI:0.000-0.655,P=0.032).Conclusion This study confirms a potential causal relationship between melasma and chronotype.It not only provides a new avenue for research into the prevention and treatment of melasma but also holds significant importance for advancing clinical practice.