预充用红细胞储存时间与体外循环心脏手术患儿术后肺炎发生风险的相关性研究OA

Objective To investigate the association between the longer red blood cell(RBC)storage duration and postoperative pneumonia(POP)in pediatric patients undergoing cardiac surgery with cardiopulmonary bypass(CPB).Methods A retrospective analysis of 444 children with congenital heart disease who underwent CPB cardiac surgery at our hospital from January 2022 to July 2024 was performed,and they were divided into fresh RBC group(storage duration≤14 d,n=214)and the older RBC group(storage duration with 14～35 d,n=230).The incidence and pathogen distribution of POP were compared between two groups.Results Among 444 enrolled patients,35 developed POP(7.89％).In the fresh RBC group,11 of 214 patients(5.14％)developed POP,compared to 24 of 230 patients(10.43％)in the older RBC group.Statistical analysis revealed a significantly higher incidence of POP in patients receiving older RBC versus fresh RBC(x2=4.242,P=0.039).Pathogen distribution in POP cases of the new RBC group was Gram-negative bacteria(n=6),Gram-positive bacteria(n=3)and others(n=2).Pathogen distribution in POP cases of the older RBC blood group was Gram-negative bacteria(n=13),Gram-positive bacteria(n=5)and others(n=6).There was no significant difference in pathogen spectrum between two groups(P=0.907).Conclusion Prolonged storage duration of priming RBCs may increase the risk of POP in children undergoing CPB cardiac surgery without altering the pathogenic bacterial spectrum.