1990-2021年中国高收缩压与高LDL胆固醇归因的缺血性脑卒中疾病负担趋势分析OA
Trend analysis on disease burden of ischemic stroke attribute to high systolic blood pressure and high LDL Cholesterol in China from 1990 to 2021
目的 基于2021 年全球疾病负担研究(GBD 2021)数据,探讨不同危险因素对中国缺血性卒中(IS)死亡和伤残调整寿命年(DALYs)的影响.方法 采用年龄-时期-队列(APC)模型,量化评估、分析了归因因素[高收缩压(SBP)、高低密度脂蛋白胆固醇(LDL-C)]造成的 IS 疾病死亡和负担的变化趋势.结果 1990-2021 年间,归因于高 SBP 的缺血性脑卒中死亡数持续增长,男性 40 岁以下及 80 岁以上人群占比较大;高 LDL-C 相关负担虽整体下降,但整体仍然呈现 U 型风险分布,在青年和老年男性较为突出.结论 高SBP 与高 LDL-C 对 IS 的影响有年龄和性别差异,未来需针对性地精准干预男性特定年龄段高危因素对 IS 的影响,以降低 IS 的死亡风险,提升人群健康水平.
Objective Based on the data from the 2021 Global Burden of Disease Study(GBD 2021),to explore the impact of different risk factors on deaths and disability-adjusted life years(DALYs)of ischemic stroke(IS)in China.Methods Age-period-cohort(APC)model was used to quantitative evaluation and analyze the trend of deaths and burden of IS attributable to high systolic blood pressure(SBP)and high low-density lipoprotein cholesterol(LDL-C).Results From 1990 to 2021,IS deaths attributed to high SBP continued to increase,with a relatively large proportion of men under 40 and over 80 years old.Although the burden related to high LDL-C decreased overall,it still showed a U-shaped risk distribution,especially in young and elderly men.Conclusions The effects of high SBP and high LDL-C on IS are different in age and gender.In the future,targeted and precise intervention on the impact of high-risk factors in specific age groups on IS is needed to reduce the risk of death from IS and improve the health of the population.
桑天乙;赵文轩;鲁晓杰
214000 无锡,江南大学附属中心医院(无锡市第二人民医院)神经外科||无锡市神经外科研究所214000 无锡,江南大学附属中心医院(无锡市第二人民医院)神经外科||无锡市神经外科研究所214000 无锡,江南大学附属中心医院(无锡市第二人民医院)神经外科||无锡市神经外科研究所
医药卫生
缺血性脑卒中高收缩压高LDL-CAPC模型
ischemic strokehigh systolic blood pressurehigh LDL-CAPC model
《临床神经外科杂志》 2026 (2)
121-125,132,6
江苏省"十四五"医学重点学科基金项目(ZDXK202227)
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