自体富血小板血浆联合透明质酸注射治疗颞下颌关节骨关节炎的临床疗效OA

Objective:To investigate the clinical efficacy of autologous platelet-rich plasma(PRP)combined with hyaluronic acid(HA)injection in the treatment of temporomandibular joint osteoarthritis(TMJOA).Methods:Eighty-two TMJOA patients admitted to our hospital from March 2023 to March 2024 were enrolled and randomly assigned to either the HA group or the combination group(n=41 per group)using a random number table.The HA group received HA injection,while the combination group received PRP in addition to HA.The following parameters were compared between the two groups before treatment(T0)and one week after the final injection(T1):maximum mouth opening(MMO),change in MMO,pain intensity and pain relief,degree of mandibular functional limitation,status of temporomandibular joint disorders,and levels of inflammatory factors.Results:At T1,the MMO in both groups had increased significantly compared to T0(P<0.05),and the MMO in the combination group was significantly higher than that in the HA group(P<0.05).The change in MMO and pain relief in the combination group were significantly greater than those in the HA group(P<0.05).At T1,visual analogue scale(VAS)scores,jaw functional limitation scale(JFLS)scores,craniomandibular index(CMI)scores,interleukin-1β(IL-1β)levels,and tumor necrosis factor-α(TNF-α)levels were significantly reduced in both groups compared to T0(P<0.05),and these values in the combination group were significantly lower than those in the HA group(P<0.05).Conclusion:PRP combined with HA injection is an effective treatment for TMJOA,as it significantly improves joint function and alleviates pain,providing a reference for clinical practice.