骨细胞钙动力学的稳态与失衡OA

The skeleton is a dynamically changing organ,and its homeostasis is maintained through the precise perception and response of osteocytes to mechanical load.The Ca2+signal,as an early key signal in this process,can convert external mechanical signals into intracellular biochemical signals,and then maintain bone homeostasis by influencing bone formation and bone resorption.In recent years,some studies have explored the normal calcium dynamics of osteocytes and found that the occurrence of bone-related diseases such as osteoporosis were closely related to the abnormal calcium dynamics of osteocytes.Therefore,this article aims to systematically review the calcium dynamics homeostasis of osteocytes and its imbalance in pathological states,in order to deeply understand the physiological regulatory basis of bone homeostasis,and provide important evidence for analyzing the pathological mechanisms of related bone diseases from the perspective of calcium dynamics of osteocytes.