子宫腺肌病相关不孕症的病理机制与临床诊疗进展OA

Adenomyosis(AM)is a common benign disease among women of reproductive age and a signif-icant cause of secondary infertility.Traditional treatments often come at the expense of fertility,making it dif-ficult to meet patients'reproductive needs.This review summarizes recent research advances in AM-associated infertility from both pathological mechanisms and clinical diagnosis and treatment perspectives.Regarding pathological mechanisms,key aspects such as abnormal uterine structure and contractile function,impaired en-dometrial receptivity,chronic inflammation and immune microenvironment dysregulation,fibrosis and tissue remodeling,and hormonal metabolic disorders are highlighted.In terms of clinical diagnosis and treatment,the application of imaging diagnostic techniques,medication and surgical strategies aimed at improving fertility outcomes,advances in minimally invasive techniques like thermal ablation,and protocol optimization in assis-ted reproductive technology ART are outlined.Currently,the pathological mechanisms of AM-associated in-fertility remain unclear,diagnosis is often subjective and experience-dependent,and treatment strategies lack high-level evidence-based support.Future research should focus on establishing a precise classification system integrating imaging and molecular biomarkers,conducting high-quality clinical studies,and further exploring the mechanisms and ef-ficacy of integrated traditional Chinese and Western medicine in improving fertility outcomes.