宣清和化方联合泼尼松治疗气阴两虚证IgA肾病的疗效及对炎症因子、肾功能的影响OA
Efficacy of Xuanqing Hehua Fang combined with prednisone in the treatment of IgA nephropathy with Qi-Yin deficiency syndrome and its influence on inflammatory factors and renal function
目的 探讨宣清和化方联合泼尼松治疗气阴两虚证免疫球蛋白A(IgA)肾病的疗效及对患者炎症因子、肾功能的影响.方法 选择2022年10月至2024年8月武汉市中医医院收治的97例气阴两虚证IgA肾病患者作为研究对象,并采用随机数字表法将其分成对照组(n=48)和中西结合组(n=49).对照组在基础治疗的基础上口服泼尼松进行治疗,中西结合组在对照组基础上联合宣清和化方进行治疗.比较2组中医疗效、中医证候积分、肾功能指标[24 h尿蛋白定量(UTP)、血肌酐(Scr)、尿素氮(BUN)]水平、血清炎症因子[血管细胞黏附分子(VCAM)-1、单核细胞趋化因子(MCP)-1]水平及药物不良反应(ADR)发生情况.结果 中西结合组中医疗效为93.88%,明显高于对照组的77.08%(P<0.05).治疗6个月后,2组中医证候积分、24 h UTP及血清SCr、BUN、VCAM-1、MCP-1水平低于治疗前,且中西结合组低于对照组,差异均有统计学意义(P<0.05).中西结合组与 对 照 组 ADR 总发生率(14.28%vs.10.42%)比较,差异无统计学意义(P>0.05).结论 宣清和化方联合泼尼松治疗气阴两虚证IgA肾病效果较好,可明显降低血清 VCAM-1、MCP-1水平,有效改善肾功能,减轻相关症状,且安全性较高.
Objective To investigate the efficacy of Xuanqing Hehua Fang combined with prednisone in treating immunoglobulin A(IgA)nephropathy with Qi-Yin deficiency syndrome and its influence on serum inflammatory factors and renal function.Methods A total of 97 patients with IgA nephropathy presenting with Qi-Yin deficiency syndrome,who were treated in Wuhan Hospital of Traditional Chinese Medicine from October 2022 to August 2024 were enrolled as research subjects,and they were divided into control group(n=48)and combined traditional Chinese and Western medicine group(n=49)by random number table.The control group received oral prednisone on the basis of standard treatment,while the combined traditional Chi-nese and Western medicine group received Xuanqing Huahe Fang on the basis of the control group.The tradi-tional Chinese medcine(TCM)efficacy,TCM syndrome scores,renal function indicators[24 hUrine protein quantification(UTP),serum creatinine(Scr),blood urea nitrogen(BUN)]levels,serum inflammatory factors[vascular cell adhesion molecule(VCAM)-1,monocyte chemotactic protein(MCP)-1]levels,as well as the in-cidence of adverse drug reaction(ADR)in the two groups were compared.Results The TCM efficacy in the combined traditional Chinese and Western medicine group was 93.88%,which was obviously higher than 77.08%in the control group(P<0.05).After 6 months of treatment,the TCM syndrome scores,24 h UTP,as well as Scr,BUN,VCAM-1,MCP-1 levels in both groups were lower than those before treatment,and which in the combined traditional Chinese and Western medicine group were lower than those in the control group,with statistically significant differences(P<0.05).The total incidence of ADR between the combined traditional Chinese and Western medicine group and the control group(14.29%vs.10.42%)had no statisti-cally significant difference(P>0.05).Conclusion Xuanqing Hehua Fang combined with prednisone has a better efficacy in patients with IgA nephropathy presenting with Qi-Yin syndrome,and it can effectively downregulate the serum VCAM-1 and MCP-1 levels,obviously improve renal function and alleviate related symptoms,with high safety.
郑帆;陈小娟;刘涛;宋琼
湖北省武汉市中医医院汉阳院区血液净化室,湖北 武汉 430050湖北省武汉市中医医院肾病科,湖北 武汉 430050湖北省武汉市中医医院肾病科,湖北 武汉 430050湖北省武汉市中医医院汉阳院区血液净化室,湖北 武汉 430050
医药卫生
宣清和化方泼尼松免疫球蛋白A肾病肾功能血管细胞黏附分子-1
Xuanqing Hehua Fangprednisoneimmunoglobulin A nephropathyrenal functionvascular cell adhesion molecule-1
《检验医学与临床》 2026 (8)
1109-1114,6
湖北省武汉市中医药科研项目(WZ22C57).
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