基于"肠-肌轴"的营养干预对肝移植受者术后衰弱及生活质量的影响OA
Effect of nutritional intervention based on the"gut-muscle axis"on postoperative frailty and quality of life in liver transplant recipients
目的 探讨基于"肠-肌轴"理论的营养干预措施对肝移植受者术后衰弱状况和生活质量的影响.方法 选取74例肝移植受者为研究对象,采用随机数字表法分为对照组和研究组,每组37例.对照组围术期接受常规护理和营养干预,研究组在此基础上采用基于"肠-肌轴"理论的营养干预措施,自术后第3天起补充双歧杆菌三联活菌散.采用肝脏衰弱指数(LFI)量表、国际体力活动问卷(IPAQ)、微型营养评定量表简表(MNA-SF)和慢性肝病生活质量量表(CLDQ)评估2组患者干预前后的衰弱程度、体力活动水平、营养状况和生活质量.结果 干预后,研究组LFI量表评分低于对照组,体力活动量高于对照组,差异有统计学意义(P＜0.05);干预后,研究组MNA-SF中活动能力、精神疾病、食欲、BMI维度评分及总分高于对照组,差异有统计学意义(P＜0.05);干预后,研究组CLDQ各维度评分及总分均高于对照组,差异有统计学意义(P＜0.05).结论 基于"肠-肌轴"理论的营养干预措施可改善肝移植受者围术期衰弱状况,促进营养状况恢复,提升生活质量.
Objective To investigate the impact of nutritional intervention measures based on the"gut-muscle axis"theory on the postoperative frailty status and quality of life in liver transplant recipients.Methods A total of 74 liver transplant recipients were selected as the study subjects.They were randomly divided into control group and study group using the random number table meth-od,with 37 cases in each group.The control group received routine nursing and nutritional interven-tion during the perioperative period,while the study group adopted nutritional intervention measures based on the"gut-muscle axis"theory in addition to the above-mentioned measures.Bifidobacterium Triple Viable Powder was supplemented from the 3rd day after surgery.The Liver Frailty Index(LFI)scale,International Physical Activity Questionnaire(IPAQ),Mini Nutritional Assessment Short-Form(MNA-SF),and Chronic Liver Disease Questionnaire(CLDQ)were used to evaluate the frailty de-gree,physical activity level,nutritional status,and quality of life of patients in the two groups before and after the intervention.Results After the intervention,the LFI scale score in the study group was lower than that in the control group,and the physical activity volume was higher than that in the con-trol group,with statistically significant differences(P＜0.05).After the intervention,the scores of activity ability,psychological status,appetite,body mass index(BMI),as well as the total score in the MNA-SF of the study group were higher than those of the control group,with statistically significant differences(P＜0.05).After the intervention,the scores of each dimension and the total score of the CLDQ in the study group were all higher than those in the control group,with statistically signifi-cant differences(P＜0.05).Conclusion Nutritional intervention measures based on the"gut-muscle axis"theory can improve the perioperative frailty status of liver transplant recipients,pro-mote the recovery of nutritional status,and enhance the quality of life.
张梦卉;鲍海力;黄茜倩
上海交通大学医学院附属瑞金医院肝移植病区,上海,200020上海交通大学医学院附属瑞金医院肝移植病区,上海,200020上海交通大学医学院附属瑞金医院肝移植病区,上海,200020
医药卫生
肝移植衰弱肠-肌轴益生菌营养干预围术期护理生活质量肝脏衰弱指数
liver transplantationfrailtygut-muscle axisprobioticsnutritional interventionperioperative nursingquality of lifeliver frailty index
《实用临床医药杂志》 2026 (5)
103-108,6
国家自然科学基金资助项目(82400768)
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