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平性靶药在风湿免疫疾病中的应用新解OA

A new interpretation of the application of targeted neutral Chinese medicines in rheumatic immune diseases

中文摘要英文摘要

风湿免疫疾病是一类以慢性炎症及免疫失衡为核心特征的自身免疫性疾病,临床常见关节肿痛、屈伸不利、口眼干燥等症靶表现,同时伴随免疫炎症指标异常、血细胞减少、尿蛋白增多等标靶改变,呈现症靶迁延、标靶顽固的临床特点.平性靶药因寒热偏性不著,既可随证配伍以治疗风湿免疫疾病相关症靶,又可依托现代药理研究调控免疫炎症指标等标靶,为风湿免疫疾病的中西医结合防治及新药研发提供理论依据与临床思路.

Rheumatic immune diseases comprise a spectrum of autoimmune disorders defined by chronic inflammation and sustained immune dysregulation.Clinically,they present with persistent symptom targets,including joint swelling and pain,restricted movement,and dryness of the eyes and mouth,while concurrently exhibiting refractory biochemical indicator targets such as elevated immune-inflammatory markers,cytopenia,and proteinuria.Targeted neutral Chinese medicines,characterized by the absence of pronounced cold or heat properties,can be flexibly prescribed according to syndrome differentiation to modulate symptom targets.Meanwhile,informed by modern pharmacological evidence,neutral-property medicines are capable of directly regulating specific biochemical indicator targets,including inflammatory mediators and immune parameters.By integrating macroscopic syndrome adjustment with microscopic target modulation,this framework provides a conceptual foundation and translational pathway for the integrated Chinese – Western management of rheumatic immune diseases and the development of novel therapeutic strategies.

谢伟楠;武哲宇;宋天泽;高文雅

北京中医药大学研究生院,北京 100029||中国中医科学院广安门医院代谢病研究所,北京 100053北京中医药大学中医学院,北京 100029北京中医药大学中医学院,北京 100029北京中医药大学北京中医药研究院,北京 100029

医药卫生

风湿免疫疾病平性靶药症靶标靶

rheumatic immune diseasestargeted neutral Chinese medicinesymptom targetsbiochemical indicator targets

《吉林中医药》 2026 (4)

483-486,4

中央高校基本科研业务费专项资金项目(2025-JYB-XJSJJ017)2025年度北京中医药大学研究生自主科研课题(ZJKT2025007)

10.13463/j.cnki.jlzyy.2026.04.018

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