代谢组学在静脉血栓栓塞性疾病中的应用进展OA

Venous thromboembolism(VTE)includes deep vein thrombosis(DVT)and pulmonary embolism(PE)with high mortality and increasing morbidity.Early recognition and diagnosis of VTE is of great clinical significance.Metabolomics is a new discipline that performs qualitative and quantitative analysis of all low molecular weight metabolites of an organism or cell during a specific physiological period.In recent years,many studies have used metabolomics analysis to determine metabolites in patients and experimental animal models with VTE,and a series of biomarkers with potential early diagnosis value have been obtained.Moreover,according to the pathway enrichment analysis of differential metabolites,it is concluded that the pathophysiological processes of VTE may be related to the imbalance of nutrient and energy metabolism,cell signaling,carnitine metabolism,purine metabolism,intestinal microbial metabolism,inflammation and oxidative stress,and genetic correlation.In addition,metabolomics also has certain value in risk stratification and prognosis,clinical efficacy evaluation and clinical monitoring of PE.However,further studies are needed to implement metabolomics for clinical application of VTE.This review summarizes the progress of metabolomics research on early diagnosis,pathogenesis,risk stratification,and clinical efficacy evaluation of VTE.