柯里拉京的药理作用及在兽医临床的应用前景OA

Corilagin is a natural gallotannin compound extracted from traditional Chinese herbal medi-cine.In recent years,the pharmacological activity and mechanism of action of corilagin have received wide-spread attention and research.The paper introduces the pharmacological effects and potential application value of corilagin in the veterinary field in terms of its acquisition,anti-inflammatory,antibacterial,antivi-ral,etc.The mechanism mainly involves interfering with the TLR2 signaling pathway to inhibit the activa-tion of NLRP3,inhibiting the NF-κB pathway activated by the TLR4-MyD88 signal,up-regulating heme oxygenase-1 to reduce the cellular ROS level,scavenging free radicals,inhibiting cyclooxygenase 2,IL-6,IL-1β and TNF-α inflammatory factors production,and reducing bacterial lipopolysaccharide-induced py-roptosis.Corilagin has broad application prospects,and its pharmacological effects provide new options and approaches for the prevention and treatment of infectious diseases and inflammatory diseases in animal husbandry production and veterinary clinical settings.