王耀献治疗糖尿病肾脏病用药规律研究OA

Objective:To explore Professor Wang Yaoxian's clinical medication rule in treating diabetic kidney disease(DKD).Meth-ods:The study focused on medical records of patients clinically diagnosed with DKD,screening DKD outpatients treated by Professor Wang Yaoxian.The records were organized and entered one by one into the Gujin Medical Case Cloud Platform.Statistical analysis,as-sociation rules,and cluster analysis were used to analyze the general patient information,the properties and meridian tropism of pre-scribed Chinese medicines,their efficacy,and common drug combinations.Complex network analysis was utilized to predict prescription patterns and to screen formulas and drugs for clearing heat,benefiting the kidneys,and resolving masses.Results:A total of 106 patients were included in this study,involving 169 Chinese medicines.The most frequently used Chinese medicines were Huangqi(Astragalus),Taoren(Peach kernel),Fuling(Poria),and Shuizzhi(Leech).The top three efficacies of the medicines were tonifying Qi and nouris-hing Yin,activating blood and resolving stasis,and clearing Heat.Regarding the Four Natures of the drugs,most of them were neutral,warm,or cold.Regarding the Five Flavors of the drugs,the main ones were sweet,pungent,and bitter.In terms of meridian tropism,the Liver,Spleen,and Kidney meridians were commonly involved.Based on association rule analysis,raw Astragalus is often paired with Po-ria,Dangshen(Codonopsis),Leech,Haizao(Seaweed),and Biejia(Turtle Shell).Hierarchical cluster analysis found five common drug combinations,such as Raw Astragalus-Peach Kernel-Codonopsis.Complex network analysis identified a core drug network con-sisting of 15 medicines including Raw Astragalus,Peach Kernel,and Poria.Conclusion:Data mining predicted that the core drugs for treating DKD mainly fall into categories of Spleen and Kidney tonifying,blood activation and mass elimination,Heat clearing and Yin nourishing as well as Liver soothing and Yang-assisting.Treatments are applied according to different disease stages,with emphasis on a combination of tonifying and dredging,staged syndrome differentiation,and overall regulation.