从"水不利则病血"病机理论阐释慢性肾脏病并发血脉病变的内涵与外延OA

Cardiovascular complications are the most common cause of death in patients with chronic kidney disease(CKD),such as vascular calcification,heart failure,and myocardial infarction.From the perspective of traditional Chinese medicine,the Kidney is con-sidered as the"Water Zang",responsible for water metabolism,whereas the Heart governs the blood and vessels,with vessels being the repository of blood.Cardiovascular diseases secondary to CKD are a typical manifestation of impaired Water metabolism leading to dys-function in blood circulation,which can be summarized in the pathogenesis principle as"Shui(Water)Bu Li Ze Bing Xue(blood)".In this process,"Shui Bu Li"includes metabolic disturbances caused by pathologic factors related to CKD,such as Phlegm,Fluids,and Dampness,while"Bing Xue"is reflected in the pathological outcomes of blood vessel insufficiency and blood stasis.Based on this un-derstanding,guided by syndrome differentiation and disease differentiation as well as the principle of treating both Water and blood sim-ultaneously,methods such as promoting Water circulation to activate blood,removing Dampness to unblock meridians,dispelling Phlegm and removing stasis as well as replenishing Essence and blood can be applied to treat CKD-related vascular lesions.