黄连解毒汤治疗神经系统疾病的研究进展OA
Research progress of Huanglian Jiedu Decoction in the treatment of neurological diseases
黄连解毒汤出自名医王焘编著的《外台秘要》,临床应用广泛,有清热解毒、泻火除烦、安神定志之功效.神经系统疾病作为严重危害人类健康的重大疾病,其防治始终是医学研究的难点与热点.大量临床证据表明,黄连解毒汤对多种神经系统疾病具有明显治疗效果.针对该复方及其组成药物的实验研究已初步阐明其药理作用机制,然而目前尚缺乏对临床应用与作用机制的系统性梳理.本文通过系统综述黄连解毒汤整方及各单味药在神经系统疾病治疗中的作用机制及临床应用现状,旨在为该方的临床合理应用提供科学依据,同时为其后续作用机制的深入研究提供理论参考.
Huanglian Jiedu Decoction is derived from"Wai Tai Mi Yao"compiled by the renowned doctor Wang Tao.It is widely used in clinical practice and has the effects of clearing heat and detoxifying,purging fire and relieving irritability,as well as calming the mind and stabilizing the will.Neurological diseases,as major diseases that seriously endanger human health,their pre-vention and treatment have always been the difficulties and hotspots in medical research.A large amount of clinical evidence indi-cates that Huanglian Jiedu Decoction has a significant therapeutic effect on a variety of neurological diseases.Experimental studies on this compound and its constituent drugs have initially clarified its pharmacological mechanism of action.However,at present,there is still a lack of a systematic review of its clinical application and mechanism of action.This article systematically reviews the mechanism of action and the current clinical application status of the entire formula of Huanglian Jiedu Decoction and each individu-al ingredient in the treatment of neurological diseases,aiming to provide a scientific basis for the rational clinical application of this formula and a theoretical reference for the in-depth study of its subsequent mechanism of action at the same time.
卢柠霞;高澳;杨津津;王业豪;刘树民;卢芳
黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040黑龙江中医药大学黑龙江中医药大学中医药研究院,黑龙江 哈尔滨 150040黑龙江中医药大学黑龙江中医药大学中医药研究院,黑龙江 哈尔滨 150040
医药卫生
黄连解毒汤神经系统疾病研究进展临床应用作用机制
Huanglian Jiedu DecoctionNeurological diseasesResearch ProgressClinical applicationMechanism of ac-tion
《海南医科大学学报》 2026 (7)
549-560,12
This study was supported by the Noncommunicable Chronic Diseases‑National Science and Technology Major Project(2024ZD0530700)the National Natural Science Foundation of China(82374067,82274125) 四大慢病重大专项(2024ZD0530700)国家自然科学基金项目(82374067,82274125)
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