支原体感染致儿童慢性咳嗽中医证型分布及与肺功能、免疫状态的相关性研究OA

Objective To investigate the distribution of traditional Chinese medicine(TCM)syndrome types in children with chronic cough caused by Mycoplasma pneumoniae(MP)infection,and to analyze the correlation of different TCM syndrome types with pulmonary function and immune status.Methods A total of 200 children with chronic cough due to MP infection,treated at Urumqi Traditional Chinese Medicine Hospital from May 2023 to May 2025 were selected.Baseline data including age,gender,and disease duration,along with TCM four-examination data were collected.The TCM syndrome types were statistically analyzed.Pulmonary function indices[forced vital capacity(FVC),the percentage of predicted FVC(FVC%),forced expiratory volume in 1 second(FEV1),the percentage of predicted FEV1(FEV1%),and FEV1/FVC ratio]and immune function indices[immunoglobulin E(IgE),T helper 1/T helper 2(Th1/Th2)ratio]were compared among children with different TCM syndrome types.The correlations between different TCM syndrome types and these pulmonary function and immune function indices were explored.Results(1)Among the 200 children,the most common TCM syndrome type was lung heat due to yin deficiency syndrome(77 cases,38.50%),followed by wind-heat invading the lung syndrome(43 cases,21.50%),wind-cold attacking the lung syndrome(36 cases,18.00%),phlegm-damp accumulating in the lung syndrome(25 cases,12.50%),phlegm-heat invading the lung syndrome(12 cases,6.00%),and lung-spleen qi deficiency syndrome(7 cases,3.50%).(2)Significant differences were found in pulmonary function indices including FVC,FVC%,FEV1,and FEV1%among the different TCM syndrome type groups(P＜0.05).A decreasing trend of the indices was observed:lung heat due to yin deficiency syndrome＞wind-cold attacking the lung syndrome＞wind-heat invading the lung syndrome＞phlegm-damp accumulating in the lung syndrome＞phlegm-heat invading the lung syndrome＞lung-spleen qi deficiency.The pulmonary function impairment was most severest in the lung-spleen qi deficiency syndrome and mildest in the lung heat due to yin deficiency syndrome.(3)Significant differences were also found in immune function indicators,including serum IgE,Th1,and Th1/Th2 ratio,among the different TCM syndrome type groups(P＜0.05).The serum IgE levels showed a decreasing trend:lung-spleen qi deficiency syndrome＞phlegm-heat invading the lung syndrome＞phlegm-damp accumulating in the lung syndrome＞wind-heat invading the lung syndrome＞lung heat due to yin deficiency syndrome＞wind-cold attacking the lung syndrome.The Th1 and Th1/Th2 levels showed a decreasing trend:wind-cold attacking the lung syndrome＞lung heat due to yin deficiency syndrome＞wind-heat invading the lung syndrome＞phlegm-damp accumulating in the lung syndrome＞phlegm-heat invading the lung syndrome＞lung-spleen qi deficiency syndrome.Immune imbalance was most pronounced in the lung-spleen qi deficiency syndrome,while the wind-cold attacking the lung syndrome demonstrated a relatively optimal immune status.Conclusion The most common TCM syndrome type in children with chronic cough caused by MP infection is lung heat due to yin deficiency syndrome.Pulmonary function indices and levels of IgE and the Th1/Th2 ratio may provide quantitative reference value for TCM syndrome differentiation and classification.