美国成年人硒摄入量与前庭平衡功能的关联研究OA

Objective To investigate the association between selenium intake and vestibular balance function,so as to provide a new approach for the prevention of vestibular-related diseases.Methods Data were obtained from 3,334 U.S.adults par-ticipating in the National Health and Nutrition Examination Survey(NHANES)from 2021 to 2023.Interviewers assessed total dietary and supplemental selenium intake using two 24-hour dietary recalls,and the modified Romberg test result was used as an objective indicator of vestibular balance function.Weighted logistic regression models were applied to analyze the association between selenium intake and positive modified Romberg test results,and restricted cubic spline(RCS)models were used to examine the dose-response relationship.Results After weighting,the study sample represented 188,916,729 U.S.adults.The overall prevalence of positive modified Romberg test results was 51.5%.The prevalence of diabetes was the highest in the high selenium intake group(11.3%).Multivariate logistic regression analysis showed that,after adjusting for confounding factors,the risk of a positive modified Romberg test result was significantly lower in the medium selenium intake group compared with the low selenium intake group(OR=0.74,95%CI:0.58-0.94,P=0.013).RCS analysis showed a significant U-shaped nonlinear dose-response relationship between selenium intake and the rate of positive modified Romberg test results(P for nonlinearity=0.021).When selenium intake was 100-250 μg/d,selenium intake was nega-tively associated with positive modified Romberg test results.Conclusion The relationship between selenium intake and the rate of positive modified Romberg test results in U.S.adults is U-shaped,indicating that an appropriate level of selenium intake is necessary to achieve optimal benefits for maintaining vestibular balance function.Furthermore,high selenium in-take is associated with diabetes status,which may affect the association between selenium intake and vestibular balance func-tion.Therefore,when assessing and formulating clinical nutrition strategies,an individual's selenium nutritional status and diabetes risk should be comprehensively considered to promote the development of personalized prevention and management strategies for vestibular dysfunction.