磁共振波普技术在神经退行性疾病中的应用研究OA

Magnetic Resonance Spectroscopy(MRS),as a non-invasive molecular imaging technique,en-ables the quantitative detection of changes in cerebral metabolites,providing crucial insights into the patho-physiology,early diagnosis,and therapeutic monitoring of neurodegenerative diseases.This review summa-rizes the applications of MRS in Alzheimer's disease(AD),Parkinson's disease(PD),multiple sclerosis(MS),and type 2 diabetes-related cognitive impairment.Studies have shown that MRS can detect early abnor-malities in neurotransmitter metabolism in the hippocampus in AD;reveal fluctuations in gamma-aminobutyr-ic acid(GABA)levels and their response to dopamine therapy in PD;identify energy metabolic alterations as-sociated with fatigue severity in MS;and demonstrate associations between prefrontal metabolites and glyce-mic control in cognitive impairment related to type 2 diabetes.Although currently limited by issues such as low sensitivity and complex signal interpretation,advances in high-field technology,ultra-fast sequences,and multimodal integration suggest broad prospects for MRS in the precise diagnosis and dynamic monitoring of neurodegenerative diseases.