泛凋亡在口腔疾病中的研究进展OA

Programmed cell death(PCD)serves as a crucial mechanism for maintaining host innate immunity,homeo-stasis,and the balance between pathogens and the host.PANoptosis is a novel form of programmed cell death that is pri-marily regulated by the PANoptosome complex and concurrently exhibits the features of apoptosis,pyroptosis,and necroptosis.Oral diseases,which significantly impact the quality of life and general health of patients,are a major con-cern.Interest in the underlying mechanisms of PANoptosis involved in oral diseases is currently increasing.This review explains the definition,characteristics,regulatory mechanisms of PANoptosis and its potential relationship with oral di-seases,aiming to offer possible solutions for the detection,prevention,and treatment of oral diseases.