养血固肾汤对髋部骨折术后肾虚型骨质疏松患者骨代谢生化指标的影响OA

Objective:To explore the effects of the blood-nourishing and kidney-tonifying decoction on the recovery and bone metabolism biochemical markers in patients with kidney-deficiency-type osteoporosis after hip fracture surgery.Methods:A prospective study was conducted,in which sixty patients with kidney-deficiency-type osteoporosis after hip fracture surgery were selected and divided into two groups using a random number table,with thirty cases in each group.The control group received conventional Western medical treatment after surgery,while the observation group was additionally treated with the blood-nourishing and kidney-tonifying Decoction based on the treatment regimen of the control group.Both groups were treated continuously for three months.To observe clinical effects,the incidence of adverse reactions,as well as changes in symptom scores,bone mineral density,and bone metabolism biochemical markers before and after treatment in both groups.Results:The total effective rate in the observation group[96.67%(29/30)]was higher than that in the control group[76.67%(23/30)](P<0.05).There was no statistically significant difference in the incidence of postoperative adverse reactions between the two groups(P>0.05).Compared with before treatment,both groups showed reductions in symptom scores for soreness and weakness of the waist and knees,aversion to cold and cold limbs,and dizziness and tinnitus after treatment(P<0.05),increases in hip bone mineral density and femoral greater trochanter bone mineral density(P<0.05),elevations in serum levels of osteocalcin,alkaline phosphatase,total procollagen type I N-terminal propeptide,and insulin-like growth factor I(P<0.05),and decreases in serum levels of intact parathyroid hormone and C-terminal telopeptide of type I collagen(P<0.05).Moreover,the improvements in these indicators were more significant in the observation group than in the control group after treatment(P<0.05).Conclusion:For patients with kidney-deficiency-type osteoporosis following hip fracture surgery,the addition of oral administration of the blood-nourishing and kidney-tonifying decoction to conventional Western medical treatment can significantly improve bone mineral density and bone metabolism biochemical markers,enhance clinical efficacy,and promote postoperative recovery from fractures.