艾司氯胺酮在围术期不同场景的临床应用进展OA

Esketamine is the S-enantiomer of ketamine.As a potent N-methyl-D-aspartate(NMDA)receptor antagonist with high affinity,it exhibits sedative,analgesic,and antidepressant properties,etc.The potency of esketamine is approximately twice that of racemic ketamine,along with several notable advantages:a rapid onset of action,mild respiratory depression,and reduced psychiatric adverse effects.In recent years,the perioperative application of esketamine has garnered increasing attention.It has shown promising clinical prospects,particularly in obstetric anesthesia,pediatric surgical anesthesia,orthopedic surgical anesthesia,painless diagnostic and therapeutic procedures,and special clinical scenarios.This paper summarizes the pharmacological properties,mechanism of action,and current clinical applications of esketamine in various clinical scenarios,with the goal of offering evidence to support its rational application in clinical practice.