高血压与焦虑抑郁共病机制的研究进展OA

There is a large and growing population of people with hypertension in China,which brings a heavy health burden to society.Epidemiological investigations have found that hypertension and anxiety and depression often coexist and influence each other.Exploring the comorbidity mechanism can help treat both the body and mind,and reduce the complications and functional damage of hypertension.In terms of pathophysiological mechanisms,the possible comorbidity pathways between the two include the renin-angiotensin-aldosterone system,the hypothalamic-pituitary-adrenal axis,insulin resistance,and the locus coeruleus-sympathetic-adrenal medulla system.In traditional Chinese medicine theory,the comorbidity of hypertension and anxiety and depression is essentially a comprehensive manifestation of the dysfunction of internal organs and the imbalance of qi,blood,yin and yang.The two are closely related through the imbalance of qi,blood,yin and yang in the liver,kidney,spleen,heart and other internal organs.In future research,by deeply exploring the comorbidity mechanism of the two,it is expected to clarify their mutual relationship,and intervening in the process can help prevent and treat the disease.