血清miR-708-3p、miR-147水平与急性心肌梗死病情的关系及对预后不良的预测价值OA
Association of serum miR-708-3p and miR-147 levels with disease severity and their prognostic value in acute myocardial infarction
目的 探究急性心肌梗死(AMI)患者血清miR-708-3p、miR-147水平与病情的关系及其水平变化对患者预后不良的预测价值.方法 选取本院在2024年1月至2025年1月收治的AMI患者96例作为研究对象;采用荧光定量PCR测定血清miR-708-3p、miR-147水平;采用Killip分级对所有研究对象进行分组;进行3个月随访分为预后良好组与预后不良组;预后不良AMI患者血清miR-708-3p、miR-147表达水平相关性分析采用Pearson法;logistic分析相关因素;ROC分析预测价值.结果 预后良好组血清miR-708-3p(0.91±0.11)、miR-147(0.96±0.19)、LVEF 水平[(43.28±5.27)％]高于预后不良组[(0.75±0.09)、(0.65±0.17)、(37.61±4.25)％](P＜0.05);预后不良 AMI 患者血清 miR-708-3p、miR-147 水平呈正相关(r=0.593,P＜0.001);AMI患者血清miR-708-3p、miR-147水平会随Killip分级升高而降低(P＜0.05);高水平的血清miR-708-3p、miR-147是预后不良保护因素(P＜0.05);血清miR-708-3p、miR-147各自单独预测及联合预测AMI患者发生预后不良曲线下面积(AUC)为0.850、0.796、0.947.二者联合优于血清miR-708-3p、miR-147各自单独预测(ZmiR-708-3p-二者联合=2.044、ZmiR-147-二者联合=3.342,P=0.021、P=0.001).结论 AMI患者血清miR-708-3p、miR-147水平显著降低,且二者表达水平会随病情程度加重而进一步降低.
Objective To investigate the association between serum miR-708-3p and miR-147 levels and disease severity in patients with acute myocardial infarction(AMI),and to evaluate their predictive value for adverse prognosis.Methods Ninety-six patients with AMI admitted to our hospital between January 2024 and January 2025 were enrolled.Serum miR-708-3p and miR-147 levels were quantified using real-time fluorescence quantitative PCR.Patients were stratified according to Killip classification to assess disease severity.All patients were followed up for 3 months and categorized into a favorable prognosis group and an adverse prognosis group.Pearson correlation analysis was used to evaluate the relationship between miR-708-3p and miR-147 levels in patients with adverse outcomes.Multiva-riate logistic regression analysis was performed to identify independent prognostic factors.Receiver operating characteristic(ROC)curve analysis was conducted to assess predictive performance.Results Serum miR-708-3p(0.91±0.11 vs.0.75±0.09),miR-147(0.96±0.19 vs.0.65±0.17),and left ventricular ejection fraction(LVEF)[(43.28±5.27)％vs.(37.61±4.25)％]were significantly higher in the favorable prognosis group than in the adverse prognosis group(all P＜0.05).In patients with adverse outcomes,serum miR-708-3p and miR-147 levels were positively cor-related(r=0.593,P＜0.001).Serum miR-708-3p and miR-147 levels progressively decreased with increasing Kil-lip class(P＜0.05).Multivariate logistic regression analysis indicated that higher serum levels of miR-708-3p and miR-147 were independent protective factors against adverse prognosis(P＜0.05).The areas under the ROC curve(AUCs)for predicting adverse prognosis were 0.850 for miR-708-3p,0.796 for miR-147,and 0.947 for their com-bined detection.Combined prediction was significantly superior to either marker alone(Z=2.044 and 3.342;P=0.021 and 0.001,respectively).Conclusion Serum miR-708-3p and miR-147 levels are significantly reduced in patients with AMI and decrease further with increasing disease severity.Combined assessment of these two biomarkers provides high predictive value for adverse short-term prognosis.
陈颂;侯彩娜;邵艳奇
平煤神马医疗集团总医院心血管内科(河南平顶山 467099)平煤神马医疗集团总医院心血管内科(河南平顶山 467099)平煤神马医疗集团总医院心血管内科(河南平顶山 467099)
医药卫生
急性心肌梗死病情程度预后miR-708-3pmiR-147
acute myocardial infarctionseverity of diseaseprognosismiR-708-3pmiR-147
《广东医学》 2026 (3)
451-455,5
河南省医学科技攻关计划项目(LHGJ20190561)
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