色氨酸代谢网络调控动物生殖系统的研究进展OA

Tryptophan(Trp)and its metabolites are extensively involved in regulating the animal reproductive system through three key metabolic pathways:the kynurenine pathway,the serotonin pathway,and the indole pathway.Current researches indicate that the Trp metabolic network modulates physiological and pathological processes such as pregnancy establishment and reproductive senescence by affecting multiple mechanisms,in-cluding the synthesis and secretion of reproductive hormones,immune microenvironment homeostasis,inflam-matory responses,and antioxidant.This article systematically reviewed recent advances in Trp metabolism within the field of animal reproduction,focusing on its roles in hormonal regulation,immune adaptation,and antioxidant stress response.It aimed to provide insights for a deeper understanding of reproductive regulatory mechanisms and for developing new strategies to improve reproductive efficiency and prevent reproductive dis-orders.[Chinese Journal of Animal Nutrition,2026,38(4):2470-2479]