枯草芽孢杆菌对动物肠道屏障功能的调控作用及其在畜牧生产中的应用OA

Bacillus subtilis(BS)is a widely used probiotic in animal husbandry presently,and often used as an additive in livestock production by adding BS to diet or drinking water.It is reported that BS can regulate the gut barrier functions of animals by maintaining the intestinal microecological balance,increasing the number of goblet cells in the intestinal tract,promoting the gene expression of mucin and tight junction proteins in the in-testine,improving the morphological structure of intestinal mucosa,and inhibiting the expression of pro-inflam-matory factors,as well as enhancing the antioxidant capacity of gut mucosa.Meanwhile,BS can effectively mitigate the structural damage and functional disorder of the intestinal barrier in animals caused by pathogenic bacteria,mycotoxins,and heat stress.Additionally,BS has been shown to increase the performance of ani-mals,improve the quality of meat and eggs,and alleviate the negative impacts of stress on animal production and health.This article expounded the regulatory effects and mechanisms of BS on the intestinal mucosal barrier functions of animals,and reviewed the research progress on the application of BS in livestock production,in order to provide references for regulating animal gut health by BS and the scientific application of BS in animal husbandry.[Chinese Journal of Animal Nutrition,2026,38(4):2382-2392]