基于黏膜免疫的胃肠道感染疫苗佐剂及递送系统的研究现状与展望OA
Current status and prospects of mucosal immunity-based vaccine adjuvants and delivery systems for gastrointestinal vaccines
疫苗是预防胃肠道感染最经济且有效的手段,而佐剂在增强和调控免疫应答方面发挥着至关重要的作用.本文评述了诱导胃肠道黏膜免疫应答的分子佐剂以及兼具佐剂效应递送系统的作用机制及优缺点,分析了当前在该类佐剂研发过程中面临的主要挑战,包括安全性、效能以及适应性等问题.此外,本文对基于黏膜免疫的胃肠道感染疫苗佐剂的未来研究方向进行了展望,包括靶向胃肠道特定受体的程序化佐剂设计、协同递送系统与佐剂的复合策略以及面向特殊人群的佐剂优化等.
Vaccines represent the most cost-effective and efficacious approach for preventing gastrointestinal infections,and adjuvants play a pivotal role in enhancing and modulating immune responses.In this article,we summarize the mechanisms,advantages,and limitations of molecular adjuvants that induce gastrointestinal mucosal immune responses,as well as of delivery systems with dual adjuvant and carrier functions.We also analyze the principal challenges encountered in the development of such adjuvants,encompassing issues related to safety,efficacy,and adaptability.Furthermore,this article provides perspectives on future research directions for mucosal immunity-based adjuvants for gastrointestinal vaccines,including design of programmed adjuvants targeting specific gastrointestinal receptors,composite strategies integrating delivery systems with adjuvants,and adjuvant optimization tailored for special populations.
李海波;王兆亿
陆军军医大学(第三军医大学)药学与检验医学系微生物与生化药学教研室,国家免疫生物制品工程技术研究中心,重庆陆军军医大学(第三军医大学)药学与检验医学系微生物与生化药学教研室,国家免疫生物制品工程技术研究中心,重庆
医药卫生
胃肠道感染疫苗佐剂递送系统
gastrointestinal infectionsvaccineadjuvantdelivery system
《陆军军医大学学报》 2026 (8)
971-979,9
Supported by the General Program of National Natural Science Foundation of China(32270988)and the General Project of Natural Science Foundation of Chongqing(CSTB2024NSCQ-MSX0981). [基金项目]国家自然科学基金面上项目(32270988)重庆市自然科学基金面上项目(CSTB2024NSCQ-MSX0981)
评论