微生物组调控衰老与类风湿性关节炎关联机制及干预策略的研究进展OA

Aging and rheumatoid arthritis(RA),while belonging to two distinct categories of physio-logical decline and pathological autoimmunity,share similar immune phenotypes and spectra of clinical compli-cations.This overlap in cross-disease phenotypes suggests they may be rooted in a common biological hub-the gut microbiome.From the perspective of immune dysregulation and gut microbiome interactions,this review systematically compares the common alterations in microbial composition,metabolic function,and barrier in-tegrity between the elderly population and RA patients.The study finds that both groups exhibit reduced mi-crobial diversity,a decreased Firmicutes/Bacteroidetes ratio,diminished short-chain fatty acid synthesis,and consequent gut barrier dysfunction and systemic low-grade inflammation.These shared gut microbiome dysbi-osis features are not only key drivers of"inflammaging"but also play critical roles in the immune activation of RA.Based on this,the review further outlines gut microbiome-targeted intervention strategies and discusses their commonalities,differences,and synergistic potential in delaying aging and alleviating RA.By integrating cross-disciplinary evidence from immunology and microecology,it reveals the deep connections between aging and RA on the gut microbiome-immune axis,providing a theoretical basis for developing common intervention strategies with both anti-inflammatory and immunoregulatory functions.