低生糖指数饼干联合司美格鲁肽对2型糖尿病肥胖的影响研究OA

Objective To investigate the effects of combining low glycemic index(GI)biscuits with Semaglutide on glycolipid metabolism,cardiopulmonary function,and the serum levels of secreted frizzled-re-lated protein 5(SFRP5)and leucine-rich alpha-2-glycoprotein-1(LRG1)in obese patients with type 2 diabetes mellitus(T2DM).Methods A total of 300 obese patients with T2DM were selected and randomly divided in-to three groups.Group A received weight management through conventional diet and conventional treatment.Group B received weight management with the addition of Semaglutide based on the treatment of Group A.Group C received weight management with the addition of low-GI biscuits based on the treatment of Group B.The changes in obesity-related indicators(BMI,waist circumference,body fat percentage),glucose and lipid metabolism[fasting plasma glucose(FPG),2-hour postprandial blood glucose(2hPG),TC,TG,LDL-C,ho-meostasis model assessment of insulin resistance(HOMA-IR)],cardiopulmonary function[left ventricular end-diastolic volume(EDV),left ventricular end-systolic volume(ESV),forced vital capacity(FVC),the rati-o of forced expiratory volume in the first second to FVC(FEV1/FVC)],and the levels of SFRP5 and LRG1 were compared among the three groups before and after treatment.Results After treatment,the BMI,waist circumference,body fat percentage,FPG,2hPG,TC,TG,LDL-C,HOMA-IR,EDV,ESV,and LRG1 levels in Group B were lower than those in Group A(P<0.05),and these indicators in Group C were lower than those in Group B(P<0.05).The FVC,FEV1/FVC,and SFRP5 levels in Group B were higher than those in Group A(P<0.05),and these indicators in Group C were higher than those in Group B(P<0.05).Conclusion The combi-nation of low GI biscuits and Semaglutide significantly reduces body weight,decreases body fat percentage,lowers ventricular load,improves glucose and lipid metabolism and cardiopulmonary function,upregulates SFRP5 expression,and inhibits LRG1 expression in obese patients with T2DM.