口腔生物膜与自体筛骨垂直板修补鼻中隔穿孔的疗效及安全性对比OA

Objective To investigate the efficacy and safety of oral biofilm combined with autologous vertical plate of the ethmoid bone for repairing nasal septal perforation.Methods A prospective selection of 136 hospitalized patients with nasal septal perforation admitted to the hospital from April 2023 to August 2025 was conducted as the study subjects.They were divided into an observation group and a control group ac-cording to a random number table method,with 68 cases in each group.All patients underwent endoscopic na-sal septal perforation repair.The control group received an autologous perpendicular plate of the ethmoid bone repair protocol,while the observation group received an oral biomembrane repair protocol.The differences be-tween the two groups were compared in terms of clinical efficacy,surgical outcomes and recovery parameters(intraoperative blood loss,operation time,range of mucosal injury,healing area at 1 week postoperatively,and postoperative healing time),Visual Analog Scale(VAS)scores,Nasal Obstruction Symptom Evaluation(NOSE)scale scores,nasal ventilation function(nasal resistance,total nasal volume,and nasal minimum cross-sectional area),and the incidence of postoperative complications.Results The observation group dem-onstrated superior efficacy compared to the control group(P<0.05).Statistically significant differences were observed between the two groups in intraoperative blood loss,operation time,extent of mucosal injury,healing area at 1 week postoperatively,and healing time(P<0.05).At 1 month and 3 months postoperatively,the VAS and NOSE scores in both groups decreased compared to those at 1 week preoperatively(P<0.05),with a more pronounced decrease in the observation group than in the control group(P<0.05).Compared with 1 week preoperatively,nasal resistance decreased at 3 months postoperatively in both groups(P<0.05),while total nasal volume and minimum cross-sectional area of the nasal cavity increased(P<0.05),and these chan-ges were more significant in the observation group than in the control group(P<0.05).No statistically sig-nificant difference was found in the incidence of postoperative complications between the two groups(P>0.05).Conclusion In the repair of nasal septal perforation,the oral biofilm repair protocol demonstrates su-perior clinical efficacy compared to the autologous ethmoid perpendicular plate repair protocol.It exhibits bet-ter performance in surgical parameters,more significant improvement in postoperative pain and nasal ventila-tion function,and equivalent safety.