多囊卵巢综合征患者口服葡萄糖耐量试验中血糖反应曲线形态特征分析OA

Objective To investigate the characteristics of blood glucose response curve patterns,glu-cose metabolism features,as well as pancreatic islet function status,in patients with polycystic ovary syn-drome(PCOS)during the oral glucose tolerance test(OGTT).Methods A retrospective analysis was con-ducted on 260 PCOS patients who visited Chongqing Traditional Chinese Medicine Hospital from August 2018 to December 2023.Blood glucose and insulin levels were measured.According to the OGTT blood glucose re-sponse curve patterns,patients were divided into a monophasic curve group and a multiphasic curve group,and glucose metabolism characteristics were compared between the two groups.Results Among PCOS patients,80.7%exhibited a monophasic response curve and 19.3%exhibited a multiphasic response curve.Compared with the monophasic curve group,the multiphasic curve group had a higher proportion of patients aged 20 to<25 years(40.0%vs.23.9%),a higher proportion of patients with normal glucose tolerance(88.0%vs.62.2%),a higher Matsuda index[4.1(3.2,5.7)vs.3.0(2.0,4.7)],and a lower homeostatic model assess-ment for insulin resistance(HOMA-IR)index[2.2(1.6,3.0)vs.2.9(1.6,4.3)],all these differences were statistically significant(P<0.05).As the peak times of blood glucose and insulin were delayed,the propor-tion of PCOS patients with normal glucose tolerance gradually decreased,while the proportion of patients with diabetes increased.Conclusion PCOS patients with a multiphasic OGTT response curve are younger,have milder insulin resistance,and are less likely to be diagnosed with diabetes.PCOS patients with delayed peak times of blood glucose and insulin are more prone to developing diabetes.