益生菌对局部晚期宫颈癌放射性损伤的影响OA

Objective To explore the effect of using probiotics on the acute radiation injury in patients with locally advanced cervical cancer.Methods A retrospective analysis was conducted on the clinical data of 148 patients who were initially treated with radiotherapy and chemotherapy at the Third Affiliated Hospital of Chongqing Medical University from January 2019 to April 2024 and were confirmed to have locally advanced cervical cancer by histopathology.The patients were divided into the probiotic group(n=84)and the control group(n=64)based on whether probiotics were used.The effects of probiotics on the incidence of acute radi-ation proctitis,cystitis and gastroenteritis were analyzed.Results The proportion of patients with an external irradiation dose>50.4 Gy and receiving vaginal brachytherapy was higher in the probiotic group than in the control group,with statistically significant differences(P<0.05).The incidence of acute radiation proctitis and cystitis was lower in the probiotic group than in the control group.The incidence of acute radiation gastro-enteritis was greater in patients undergoing chemotherapy than in those not,and in those with an external irra-diation dose>50.4 Gy than in those with≤50.4 Gy,with statistically significant differences(P<0.05).The results of multivariate logistic regression analysis showed that the probiotic users had 82.8%(OR=0.172,95%CI:0.080-0.371)and 51.5%(OR=0.485,95%CI:0.244-0.965)reduced incidence of radiation proc-titis and cystitis compared to non-users.The incidence of acute radiation gastroenteritis in patients with an ex-ternal irradiation dose>50.4 Gy and those receiving vaginal brachytherapy was 4.547 times(OR=4.547,95%CI:1.796-11.514)and 5.502 times(OR=5.502,95%CI:0.690-43.888)that of patients with≤50.4 Gy and those without vaginal brachytherapy,respectively.Conclusion The use of probiotics can reduce the in-cidence of radiation-induced proctitis and cystitis in patients with locally advanced cervical cancer.