磁共振成像结合人工智能在宫颈癌精准诊疗中的研究进展OA

Precision diagnosis and therapy for cervical cancer,a major global public health challenge,are hindered by tumor heterogeneity and the limitations of conventional assessment methods.The integration of artificial intelligence(AI)with multi-parametric MRI(mp-MRI)provides a new paradigm for non-invasively assessing tumor pathophysiology.Research in this field has established an AI-driven,hierarchical technical framework spanning from anatomical localization to molecular characterization:At the anatomical level,the introduction of novel architectures such as Transformer and state space models(SSM)has overcome the receptive field limitations of convolutional neural networks(CNN),achieving precise lesion segmentation within complex pelvic anatomical backgrounds.At the functional level,AI optimizes the parameter fitting models of intravoxel incoherent motion(IVIM),diffusion kurtosis imaging(DKI),and dynamic contrast-enhanced MRI(DCE-MRI)via deep neural networks(DNN),significantly enhancing the robustness of quantitative parameters.Furthermore,it utilizes habitat analysis techniques to quantify intra-tumoral microscopic heterogeneity for predicting lymph node metastasis(LNM)and lymphovascular space invasion(LVSI).At the molecular level,radiomics and radiogenomics leverage machine learning to deeply mine high-dimensional imaging features,establishing non-linear mappings between imaging phenotypes and molecular characteristics such as gene mutations and the immune microenvironment.Additionally,the integration of circulating tumor DNA(ctDNA)data facilitates the formation of a multi-modal"imaging biopsy"paradigm.This AI-empowered three-stage system(segmentation-functional analysis-molecular decoding)connects the entire chain of precision diagnosis and treatment for cervical cancer.However,the clinical translation of this system is still limited by systemic challenges such as inadequate data standardization,limited model generalizability,and poor interpretability.This article systematically reviews these advancements,deeply analyzes technical principles,clinical values,and practical dilemmas,aiming to provide a forward-looking perspective for promoting this technology towards clinically-oriented individualized precision medicine.