MRI影像组学对原发性中枢神经系统淋巴瘤的鉴别诊断与预后评估的研究进展OA

Primary central nervous system lymphoma(PCNSL)is an aggressive extranodal lymphoma that remains clinically rare.Owing to its highly invasive tumor biology and the fact that therapeutic options are constrained by the blood-brain barrier,patients with PCNSL exhibit markedly poor overall prognosis,making PCNSL one of the most challenging lymphoma subtypes in contemporary clinical oncology.Although MRI is now widely used for the diagnosis and grading of central nervous system tumors,the underlying molecular mechanisms,tumor microenvironment,and biological processes within the lesions still require further exploration.Radiomics can mine deeper information from the tumor,enabling more objective and comprehensive assessment of tumor heterogeneity,and has shown great potential for diagnosis,grading,and prognosis prediction across various cancers.This review focuses on the latest applications and research advances of MRI-based radiomics in the diagnosis and prognostic prediction of PCNSL,highlights current limitations,and outlines future research directions,aiming to further advance the field.